Cutaneous Sarcoidosis: A dermatologic Masquerader -- American Family Physician

Recognition of Skin Lesions Recognition of cutaneous lesions is important because they provide a visible clue to the diagnosis and are an easily accessible source of tissue for histologic examination. Punch or incisional wedge biopsy is typically used to obtain a sample of skin that includes the dermis. If noncaseating granulomas are found (Figure 1), tissue culture may be necessary to exclude infectious causes. Most authors divide lesions of cutaneous sarcoidosis into nonspecific and specific types. S arcoidosis is a systemic disease that can involve almost any organ system. Infiltration with noncaseating granulomas is the hallmark of the disease, and it may result in various clinical manifestations. The underlying cause of sarcoidosis remains unknown. Although the disease can occur at any age, in persons of either gender, and in all races, older studies suggest that sarcoidosis more frequently affects persons who are of Scandinavian, Irish, or black descent.